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Investigador en Biología Molecular y Bioquímica, con enfoque en cáncer y agentes oportunistas. El Dr. Greco Hernández lleva la dirección de uno de los grupos de investigación en el Instituto Nacional de Cancerología en la Ciudad de México. Cuenta no S.N.I. Nivel 2 y es graduado de la Facultad de Ciencias en la Universidad Nacional Autónoma de México. Cuenta con doctorado en Biología Molecular en el Centro de Biología Molecular “Severo Ochoa” en la Universidad Autónoma de Madrid, España.

Trayectoria Científica

1ro/Ago/1999  31/Dic/2004. Postdoctoral Fellow. Rolando Rivera / Thomas Jovin. Abt. Molekulare Biologie.

Max-Planck-Institute für biophysikalische Chemie.

Göttingen, Alemania.

1/Ene/2005  31/Ene/2007. Posdoctoral Fellow. Lab. Hans Trachsel.

Institute für Biochemie und Molekulare Medizin.

Universität Bern.

Bern, Suiza.

01/Feb/2007  30/Jun/2011. Research Associate. Paul Lasko / Nahum Sonenberg. Depto. Biología / Depto. de Bioquímica.

McGill University.

Montreal, Canadá.

Publicaciones por el Dr. Greco Hernández Ramírez
(* denota autor correspondiente)

Lazcano, A., Valverde, V., Hernández, G., Gariglio, P., Fox, G. E. and Oro, J. (1992). On the early emergence of reverse transcription: theoretical basis and experimental evidence. J. Mol. Evol. 35: 524-536.

Hernández, G. and Sierra, J.M. (1995). Translation initiation factor eIF-4E from Drosophila: cDNA sequence and expression of the gene. Biochim. Biophys. Acta 1261: 427-431.

Hernández, G., Diez del Corral, R., Santoyo, J., Campuzano, S. and Sierra, J.M. (1997). Localization, structure and expression of the gene for translation initiation factor eIF4E from Drosophila. Mol. Gen. Genet. 253: 624-633.

Hernández, G., Castellano, M.M., Agudo, M. and Sierra, J.M. (1998). Isolation and characterization of the cDNA and the gene for eukaryotic translation initiation factor 4G from Drosophila. Eur. J. Biochem. 253: 27-35.

Pomar, N., Berlanga, J. J., Campuzano, S., Hernández, G., Elias, M. and Haro, C. (2003). Functional characterization of Drosophila PERK eukaryotic initiation factor 2a (eIF2a) kinase. Eur. J. Biochem. 270: 293-306.

Hernández, G., Lalioti, V.S., Vandekerckhove, J., Sierra, J.M. and Santarén, J.F. (2004). Identification and characterization of the expression of the translation initiation factor 4A (eIF4A) from Drosophila. Proteomics 4: 316-326.

Hernández, G., Vazquez-Pianzola, P., Zurbriggen, A., Altmann, M., Sierra, J.M. and Rivera-Pomar, R. (2004). Two functionally redundant isoforms of Drosophila eIF4B are involved in cap-dependent translation, cell survival and proliferation. Eur. J. Biochem. 271: 2923-2936.

Hernández, G., Vázquez-Pianzola, P., Sierra, J.M. and Rivera-Pomar, R. (2004). Internal Ribosome Entry Site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos. RNA 10: 1783-1797.

Hernández, G.*, Altmann, M., Sierra, J.M., Urlaub, H., Diez del Corral, R., Schwartz, P. and Rivera-Pomar, R. (2005). Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila. Mech. Dev. 122: 529-543.

Hernández, G.* and Vázquez-Pianzola, P. (2005). Functional diversity of the eukaryotic translation initiation factors belonging to eIF4 families. Mech. Dev. 122: 865-876.

Vázquez-Pianzola, P., Hernández, G., Suter, B. and Rivera-Pomar, R. (2007). Different modes of translation for hid, grim and sickle mRNAs in Drosophila. Cell Death Diff. 14: 286-295.

Hernández, G.* (2008). Was the initiation of translation in early eukaryotes IRES-driven? Trends Biochem. Sci. 33: 58-64.

Hernández, G.* (2009). On the origin of the cap-dependent initiation of translation in eukaryotes. Trends Biochem. Sci. 34: 166-175.

Hernández, G.*, Altmann, M. and Lasko, P. (2010). Orgins and evolution of the mechanisms regulating translation initiation in eukaryotes. Trends Biochem. Sci. 35: 63-73.

Fonseca, B.D., Alain, T., Finestone, L.K., Huang, B.P., Rolfe, M., Jiang, T., Yao, Z., Hernández, G., Bennett, C.F. and Proud, C.G. (2011). Pharmacological and genetic evaluation of proposed roles of MEKS, ERKs and p90RSKS in the control of mTORC1 signaling by phorbol esters. J. Biol. Chem. 286: 27111- 27122.

Tettweiler, G., Kowanda, M., Lasko, P., Sonenberg, N. and Hernández, G.* (2012). The distribution of eIF4E-family members across Insecta (2012). Comp. Funct. Genomics 2012: 960420.

Hernández, G.*, Proud, C., Preiss, T. and Parsyan, A. (2012). On the diversification of the translational apparatus across eukaryotes. Comp. Funct. Genomics 2012: 256848.

Parsyan, A., Hernández, G. and Materissian, S. (2012) Translation initiation in colorectal cancer. Cancer and Metastasis Reviews 31: 387-395.

Ferrero, P., Layana, C., Paulucci, E., Gutierrez, P. Hernández, G. and Rivera-Pomar, R. (2012). Cap-binding-independent recruirment of eIF4E to cytoplasmic foci. Biochem. Biophys. Acta. 1823: 1217-1224.

Hernández, G., Han, H., Gandin, V., Fabian, L., Ferreira, T., Zuberek, J., Sonenberg, N., Brill, J.A. and Lasko, P. (2012). Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development 139:3211-3220.

Hernández, G.* (2012). Editorial: Translational control across eukaryotes. Comp. Funct. Genomics 2012:317690.

Hernández, G., Miron, M., Han, H., Liu, N., Magescas, M., Frank, F., Siddiqui, N., Sonenberg, N. and Lasko, P. (2013). Mextli is a novel eIF4E-binding protein that promotes translation in Drosophila. Mol. Cell. Biol. 33: 2854-2864.

Fonseca, B.D., Zakaria, C., Jia, J.J., Graber, T.E., Svitkin, Y., Tahmasebi, S., Healy, D., Hoang, H.D., Jensen, J.M., Diao, I.T., Lussier, T., Dajadian, A., Padmanabhan, N., Wang, W., Matta-Camacho, E., Hearnden, J., Smith, E.M., Tsukumo, Y., Yanagiya, A., Morita, M., Petroulakis, E., González, J.L., Hernández, G., Alain, T. and Damgaard, C.K. (2015). La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1). J. Biol. Chem. In press.

Capítulos de Libros

Hernández, G.* and Tettweiler, G. (2012). Protein Abundance Variation. En: Systems Biology. Advances in Molecular Biology and Medicine, (Ed. Robert. A. Meyer), pp. 117-137. 1st Edition. Wiley-Blackwell, Weinheim, Alemania.

Hernández, G.* (2012). On the emergence and evolution of the eukaryotic translation apparatus. En: Cell-Free Protein Synthesis, (Ed. Manish Biyani), pp. 31-50. InTech. Rijekra, Croacia.

Editor

Hernández, G., Proud, C. Parsyan A. and Preiss, T. Editor in chief of the special issue “Translational control across eukaryotes”. Comparative and Functional Genomics (2012), vol. 2012.

Hernández, G. and Jagus, R. (2015). Evolution of the protein synthesis apparatus. Springer, Weinheim, Alemania. En preparación.

Investigador en Cáncer y Biología Molecular